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Úloha osy PD-1/PD-L1 při infekci \kur{Borrelia burgdorferi} u myší
PALOUNKOVÁ, Anna
Borrelia burgdorferi, the causative agent of Lyme disease, induces upregulation of inhibitory immune checkpoint PD-L1 in mice. We studied if the blockade of PD-1/PD-L1 axis by neutralizing antibodies influences the proliferation of T lymphocytes and cytokine milieu in imunological synapsis between murine dendritic cells and T cells in vitro.
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Vliv klíštěcích slin na fagocytózu borelií dendritickými buňkami
MARŠÁLKOVÁ, Eliška
In this study we examined the effect of the tick saliva from I. ricinus and the effect of recombinant protein IRS-2 from the saliva of I. ricinus on dendritic cells derived from the mice bone marrow. We studied their effect on the production of cytokines by dendritic cells after the stimulation by B. burgdorferi, their effect on the expression of genes, that participate in phagocytosis, and the impact of the tick saliva on phagocytosis of B. burgdorferi by dendritic cells.
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Effect of \kur{Ixodes ricinus} feeding duration on transmission of the spirochete \kur{Borrelia afzelii}
CHLASTÁKOVÁ, Adéla
Lyme borreliosis is a multisystem infectious disease caused by tick-borne spirochetes belonging to the \kur{Borrelia burgdorferi} sensu lato complex. It is generally believed that if a tick is attached for less than 24 hours, infection is unlikely because it requires between 36 and 48 hours of attachment for \kur{Borrelia burgdorferi} to travel from within the tick into its saliva. Nevertheless, there is evidence that transmission to a host may even occur in the early phases of tick feeding. We investigated the dynamics of \kur{Borrelia afzelii} transmission by nymphal \kur{Ixodes ricinus} ticks with special respect to the first day of tick attachment.
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Vector-pathogen-host interaction on the example of spirochetes Lyme boreliosis disease (and tick-borne encephalistis virus)
VAVRUŠKOVÁ, Zuzana
This study was focused on vector-pathogen-host interaction. Questing ticks from field were tested for presence of Borrelia burgdorferi s.l. and host DNA. Small rodents were trapped, ticks were collected from them, infestation patterns were estimated regarding the species and stage of ticks and species, sex and body weight of the host. Ticks aquired from hosts were tested for presence of Borrellia burgdorferi s.l. and tick-borne encephalitis virus. Both results from identification of hosts and from detection of pathogens were compared to be able to investigate interactions between host, vector and pathogen.
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